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Sökning: swepub > Umeå universitet > Riboli Elio > Chirlaque Maria Dolores > Trichopoulou Antonia > Panico Salvatore > Jenab Mazda > (2020) > Healthy lifestyle a...

Healthy lifestyle and the risk of pancreatic cancer in the EPIC study

Naudin, Sabine (författare)
International Agency for Research on Cancer, World Health Organization
Viallon, Vivian (författare)
International Agency for Research on Cancer, World Health Organization
Hashim, Dana (författare)
Icahn School of Medicine at Mount Sinai
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Freisling, Heinz (författare)
International Agency for Research on Cancer, World Health Organization
Jenab, Mazda (författare)
International Agency for Research on Cancer, World Health Organization
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization
Perrier, Flavie (författare)
International Agency for Research on Cancer, World Health Organization
McKenzie, Fiona (författare)
International Agency for Research on Cancer, World Health Organization
Bueno-de-Mesquita, H. Bas (författare)
Imperial College London,University Medical Center Utrecht,National Institute for Public Health and the Environment (RIVM)
Olsen, Anja (författare)
Danish Cancer Society
Tjønneland, Anne (författare)
Danish Cancer Society,University of Copenhagen
Dahm, Christina C. (författare)
Aarhus University
Overvad, Kim (författare)
Aarhus University,Aalborg University
Mancini, Francesca R. (författare)
Institut Gustave Roussy
Rebours, Vinciane (författare)
Beaujon Hospital,Paris Diderot University
Boutron-Ruault, Marie Christine (författare)
Institut Gustave Roussy
Katzke, Verena (författare)
German Cancer Research Centre
Kaaks, Rudolf (författare)
German Cancer Research Centre
Bergmann, Manuela (författare)
German Institute of Human Nutrition
Boeing, Heiner (författare)
German Institute of Human Nutrition
Peppa, Eleni (författare)
Hellenic Health Foundation, Athens
Karakatsani, Anna (författare)
National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
Trichopoulou, Antonia (författare)
National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
Pala, Valeria (författare)
Istituto Nazionale dei Tumori
Masala, Giovana (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
Panico, Salvatore (författare)
University of Naples Federico II
Tumino, Rosario (författare)
Civic and M.P Arezzo Hospital
Sacerdote, Carlotta (författare)
Citta' della Salute e della Scienza Hospital-University of Turin
May, Anne M. (författare)
University Medical Center Utrecht
van Gils, Carla H. (författare)
University Medical Center Utrecht
Rylander, Charlotta (författare)
UiT The Arctic University of Norway, Tromsø
Borch, Kristin Benjaminsen (författare)
UiT The Arctic University of Norway, Tromsø
Chirlaque López, María Dolores (författare)
University of Murcia
Sánchez, Maria Jose (författare)
University of Granada
Ardanaz, Eva (författare)
Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP),Navarre Public Health Institute (ISPN)
Quirós, José Ramón (författare)
Public Health Directorate
Amiano Exezarreta, Pilar (författare)
Sund, Malin (författare)
Umeå universitet,Umeå University,Kirurgi
Drake, Isabel (författare)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
Regnér, Sara (författare)
Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
Travis, Ruth C. (författare)
University of Oxford
Wareham, Nick (författare)
University of Cambridge
Aune, Dagfinn (författare)
Imperial College London,Bjørknes University College,Oslo university hospital
Riboli, Elio (författare)
Imperial College London
Gunter, Marc J. (författare)
International Agency for Research on Cancer, World Health Organization
Duell, Eric J. (författare)
Catalan Institute of Oncology
Brennan, Paul (författare)
International Agency for Research on Cancer, World Health Organization
Ferrari, Pietro (författare)
International Agency for Research on Cancer, World Health Organization
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 (creator_code:org_t)
2019-09-28
2020
Engelska 12 s.
Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 35:10, s. 975-986
Relaterad länk:
http://dx.doi.org/10...
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https://munin.uit.no...
https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants’ shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e−09) and 0.77 (0.72, 0.82; ptrend = 1.7e−15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e−04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

EPIC
Healthy Lifestyle Index
Pancreatic cancer
Population attributable fraction
Prospective study
Pancreatic cancer

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